News | Page 8 | Pediatrics

Dr. Kimberley Chien Promoted to Associate Professor of Clinical Pediatrics

January 10, 2023

The Department of Pediatrics is pleased to announce the promotion of Kimberley Chien, M.D. to Associate Professor of Clinical Pediatrics, effective December 1, 2022.

Dr. Chien is an Associate Attending Pediatrician at New York-Presbyterian Komansky Children’s Hospital and New York-Presbyterian/Weill Cornell Medical Center. She is board-certified in pediatrics and pediatric gastroenterology. She received a B.S. in Neuroscience at Tufts University and earned her medical degree at SUNY-Downstate Medical College of Brooklyn. She completed her pediatric internship and residency training at NYU School of Medicine and attended New York-Presbyterian Morgan Stanley Children’s Hospital/Columbia University Medical Center to complete fellowship training in Pediatric Gastroenterology, Hepatology, and Nutrition.

10 Ways to Keep your Child’s Digestive Tract Healthy this Holiday Season

December 16, 2022

This article was originally posted in the WCM Patient News

Stuffing and candy and pie, oh my! ‘Tis the season for overeating, and for eating too many of the “wrong” foods without enough of the right ones to counterbalance them. Seasonal excess is tough enough for our adult digestive tracts to handle, but our children may have an even harder time digesting all those tempting, less-than-healthy holiday offerings.

The good news is that there are plenty of steps parents can take to foster healthy eating while indulging in just a few holiday treats and a limitless amount of family fun.

Dr. Kimberley Chien, assistant attending pediatrician at NewYork-Presbyterian Hospital’s Phyllis and David Komansky Center for Children's Health and assistant professor of pediatrics at Weill Cornell Medicine, offers the following tips that will help keep your kids’ GI tracts in tip-top shape while building healthy eating habits for life.

Experimental Vaccines Offer Long-term Protection Against Severe COVID

December 2, 2022

This article was originally posted on the WCM Newsroom

In 2021, a group of scientists led by researchers at the University of North Carolina at Chapel Hill, Weill Cornell Medicine and NewYork-Presbyterian reported that the Moderna mRNA vaccine and a protein-based vaccine candidate containing an adjuvant, a substance that enhances immune responses, elicited durable neutralizing antibody responses to SARS-CoV-2 during infancy in pre-clinical research.

Now a follow-up study by the same group, published Dec. 1 in Science Translational Medicine, has found that the 2-dose vaccines still provide protection against lung disease in rhesus macaques one year after they had been vaccinated as infants.

Unusual Type of Antibody Shows Ultrapotent Activity Against Zika

November 22, 2022

This article was originally posted in the WCM Newsroom.

An unusual type of antibody that even at miniscule levels neutralizes the Zika virus and renders the virus infection undetectable in preclinical models has been identified by a team led by Weill Cornell Medicine, NewYork-Presbyterian and National Institutes of Health (NIH) investigators.

Because Zika can cause birth defects when passed from a pregnant person to their fetus, this discovery could lead to the development of therapies to protect babies from the potentially devastating effects of this disease.

In research published Nov. 18 in Cell, the investigators isolated an ultrapotent immunoglobulin M (IgM) antibody — a five-armed immune protein that latches onto the virus— using blood cells taken from pregnant people infected with Zika. In experiments with mice, they determined that the antibody not only protected the animals from otherwise lethal infections, but also suppressed the virus to the point that it could not be detected in their blood.

Dr. Eric Mallack to Co-lead "NEXUS" Trial to Test Novel Drug in Patients with Early-Stage Cerebral Adrenoleukodystrophy

November 3, 2022

Eric J. Mallack, M.D., Director of the Leukodystrophy Center and Assistant Professor of Pediatrics and Neurology at Weill Cornell Medicine is the Co-Principal Investigator of a new phase 2/3 clinical trial, sponsored by Minoryx Therapeutics. The “NEXUS” study will assess the efficacy and safety of leriglitazone in pediatric patients with early-stage cerebral adrenoleukodystrophy (cALD).

Alongside Co-PI, Patricia Musolino, MD, PhD from Massachusetts General Hospital, the team aims to confirm whether researchers can halt or stabilize early cerebral ALD, a progressive inflammatory neurodegenerative disease of childhood, with leriglitazone - a novel, orally bioavailable and selective PPAR gamma agonist. If proven effective, this will be the first non-transplant-related therapy (e.g. stem cell transplant and gene therapy) that can halt this childhood neurodegenerative disorder. And if delivered early enough, it may stop the disease in the pre-symptomatic period of disease, thus preserving full neurological function in these patients.

The imaging outcomes in the study were developed from Dr. Mallack’s quantitative MRI research in lesion volumetry (PMID: 34503945), and Dr. Musolino’s work in MR Perfusion (PMID: 22961546).

NIH grant funds lupus research in children

October 25, 2022

This article was originally posted on EurekAlert.

A multi-institutional team of scientists, led by researchers at Weill Cornell Medicine’s Gale and Ira Drukier Institute for Children's Health, have received a five-year $8.297 grant to continue funding a Center for Lupus Research. The grant, awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health, will allow researchers to explore the underlying mechanisms of systemic lupus erythematosus (SLE) in children with the goal of better tailoring treatment.

“Pediatric lupus is often underrecognized, but up to a quarter of people with the illness have disease that starts in childhood,” said Dr. Virginia Pascual, program director of the Center for Lupus Research and the Drukier Director of the Drukier Institute for Children's Health at Weill Cornell Medicine.

Drs. Sheila Carroll and Patrick Flynn Appointed Interim Co-Chiefs of Pediatric Cardiology

October 17, 2022

We are pleased to announce Sheila J. Carroll, M.D. and Patrick A. Flynn, M.D. have been named Interim Co-Chiefs of Pediatric Cardiology, effective October 1, 2022. Dr. Carroll, who serves as the Director Fetal Cardiology, and Dr. Flynn, who serves as the Director of the Echocardiography Lab, will provide proven leadership and oversight for the Division’s activities, including liaising with Department administration and supporting the Department’s vision and missions in patient care, research, and education as well as quality, diversity, and inclusion.

We are grateful for the excellence and innovation of current chief Dr. Ralf Holzer. Under Dr. Holzer’s leadership from 2017 to 2022, the Division dramatically grew its pediatric cardiac catheterization program, expanded its clinical Pediatric Cardiology practice to Lower Manhattan, strengthened relationships with partner departments and institutions, and achieved the first premature infant transcatheter PDA closure in Manhattan. We wish Dr. Holzer well in his future endeavors.

Dr. Lisa Roth Awarded Grant to Develop a Novel Approach to the Treatment of EBV-infected Lymphomas

October 5, 2022

Lisa Roth, M.D., Director of Pediatric Oncology and an associate professor in pediatrics, medicine and pathology and laboratory medicine at Weill Cornell Medicine has been awarded a grant from the NIH National Cancer Institute for her study, “Targeting Latency Switch in EBV+ Lymphomas”.

Epstein-Barr virus (EBV) is a herpesvirus that infects B cells, the immune cells that make antibodies and that cause lymphoma when the cells grow uncontrollably. Many EBV-infected lymphoma cells are able to evade an immune response against EBV because the virus establishes a latent, or largely dormant, infection, restricting expression of its genes so that only one protein, which elicits a weak immune response, is expressed. In this study, Dr. Roth will develop a novel approach to the treatment of EBV-infected lymphomas by using drugs that affect gene expression to convert dormant virus in tumors to a more active state, thereby sensitizing resistant tumors to an anti-tumor immune response directed at EBV.

Karam, Nellis, Receive R34 Award for Platelet Transfusion Strategies Pilot Study

September 28, 2022

This article was originally posted in the Yale Medicine Newsroom.

In a first of its kind pilot study, Oliver Karam, MD, PhD, chief of pediatric critical care at Yale School of Medicine, and Marianne Nellis, MD, MS, associate professor in pediatric critical care at Weill Cornell Medicine, have been funded by the National Institutes of Health (NIH) to study different platelet transfusion thresholds for children supported by ECMO machines (extracorporeal membrane oxygenation). The ECmo hemoSTAtic Transfusions In Children (ECSTATIC) pilot trial will test two different platelet transfusion strategies, based on two different platelet count thresholds in critically ill infants and children.

Patients have received blood transfusions since as far back as 1820 but they became more widely used on the battlefield during World War I. Ever since, people have been giving and receiving blood, but there are relatively few studies to help doctors determine when and how blood products may be used most effectively.

Understanding Polio's Emergence in New York

September 27, 2022

This article was originally posted in the WCM Newsroom.

Unlike COVID-19 or the flu, polio is entirely and permanently preventable. In fact, until this year, there had not been one case of polio that originated in this country since 1979. A case in 1993 was brought to these shores by someone who had traveled to a country where the disease was endemic.

As long as you and your children are vaccinated, you have nothing to worry about. But if you are unvaccinated or under-vaccinated, doctors and public health officials urge you to waste no time in getting the polio vaccine, which confers lifelong protection against a potentially disabling disease.

The public health picture

A handful of polio-caused paralysis cases in New York, London and Jerusalem may seem minor compared to the massive global impact of the COVID-19 pandemic. But in public health terms, the recent polio outbreak is anything but minor. That’s because the poliovirus causes paralysis in fewer than 1 in 200 of the people it infects, according to the World Health Organization (WHO). Think of the one case of paralysis in New York’s Rockland County as the tip of a very large iceberg.