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The Division of Critical Care Medicine supports active pediatric delirium and pediatric transfusion medicine research programs. In addition, our investigators are involved in numerous other research projects ranging from critical care education and simulation to international health and care of the critically ill pediatric cancer patient.
Delirium Research
- Delirium Point Prevalence: a 25-site point prevalence study coordinated by the Department of Pediatrics, including 994 children with 25-percent rates of delirium in pediatric intensive care units across the United States
- Pediatric Intensive Care Unit (PICU) Liberation: a seven-site QI project, sponsored by the Society of Critical Care Medicine (SCCM), that has collaboratively implemented six bundles of care for optimizing pain control, minimizing sedation and delirium, weaning ventilators, mobilizing patients and involving families in PICU care
- Transfusion-Associated Delirium: a 29-site study coordinated by the Department of Pediatrics, designed to assess the effect of red blood cell transfusions on the development of delirium.
- Dexmedetomidine for the Prevention of Delirium: a retrospective study evaluating the efficacy of dexmedetomidine in the prevention of PICU delirium.
- The Role of Benzodiazepines in Transitions to Delirium: a retrospective analysis of the role of sedatives and analgesics in the development of delirium in PICU patients, with a specific emphasis on the role of benzodiazepines
LINK: Dr. Chani Traube's Delirium Research Program webpage
Transfusion Medicine Research
- Point Prevalence of Platelet Transfusions in Critically Ill Children (P3T): an international point prevalence study of platelet transfusions in critically ill children, coordinated by the Department of Pediatrics and involving 85 centers in 14 countries
- Age of Blood in Children in Pediatric Intensive Care Units (ABC PICU): a prospective, international, multi-center clinical trial which tracks the development of organ dysfunction in children receiving red cell transfusions
- Massive Transfusion in Children (MATIC): an international, multi-center database of massive transfusions in critically ill children
- Predicting Bleeding in Critically Ill Children with Thrombocytopenia (PREDICT): a multi-center, observational study of laboratory assays that may predict bleeding in critically ill children with thrombocytopenia
Other Research Projects
- Tanzania - Recognition and Stabilization of Pediatric Patients with Critical Illness: an international project conducted with the Weill Bugando Hospital in Mwanza, Tanzania, American Heart Association and Children's Hospital of Philadelphia, aimed at recognition and initial stabilization of critical illness in pediatric patients
- The National Emergency Airway Registry for Children (NEAR4KIDS): a multi-center, prospective registry for advanced airway management in pediatric ICUs, to improve advanced airway management and develop best practices for tracheal intubation in children
- Pathogen Identification in Pediatric Hematopoietic Stem Cell Transplant Patients with Suspected Lower Respiratory Tract Infection: a multi-center, prospective study to identify pathogens associated with pneumonia in pediatric, hematopoietic stem cell transplant patients
- Survey of Intensive Care Management of Respiratory Failure in Children with Hematopoietic Stem Cell Transplants (SIRCH): a multi-center, retrospective review of ventilation practices in North America, to support pediatric patients with acute respiratory failure after allogeneic hematopoietic stem cell transplant
- Sepsis Prevalence, Outcomes and Therapy (SPROUT): an international, multi-center, point prevalence study of sepsis, specifically concerning global epidemiology, comparing research and clinical criteria to define sepsis
- Pediatric Acute Respiratory Distress Incidence and Epidemiology (PARDIE): an international, multi-center, point prevalence study of the epidemiology of ARDS in the global pediatric population using the recently developed (2015) Pediatric Acute Lung Injury Consensus Conference (PALICC) definitions for PARDS
- Early Mobilization: a multi-center, point prevalence study evaluating the implementation and standardization of early mobilization of mechanically ventilated patients in PICUs
- Venous Thromboembolism (VTE) Prevention: a bi-campus (with the Columbia College of Physicians and Surgeons) QI initiative to standardize a screening tool for VTE, track incidence and promote prevention
- Veno-Occlusive Disease Study Group: a 12-institution, expert study group to develop guidelines for optimization of management of children with veno-occlusive disease of the liver following pediatric, hematopoietic stem cell transplant
- Pediatric Airway Pressure Release Ventilation (APRV): a retrospective analysis of the role of APRV in the treatment of pediatric acute respiratory distress syndrome
- Evaluation of a Pediatric Vancomycin Dosing Guideline: a retrospective QI project assessing the compliance to and the safety and efficacy of a pediatric vancomycin dosing guideline
- Pediatric Trauma Procedural Skills TrainingUsing a Novel Biosynthetic Tissue: evaluation of the use of SynDaver for placement of chest tubes and cricothyrotomy in simulated trauma patients
- Comparison of Lung Ultrasound to Chest X-Ray in Pediatric Patients Following Thoracoabdominal Resection: a prospective analysis of chest imaging by ultrasound as compared to chest X-ray in pediatric patients with advanced neuroblastoma following thoracoabdominal surgical resection
- Evaluation of the Implementation of a Rapid Response Team (RRT) in a Pediatric Cancer Hospital: a QI project evaluating implementation, effectiveness and outcomes of an RRT in a pediatric cancer hospital