The Child Neurology Division of Weill Cornell Medicine engages in a wide range of research activities to expand knowledge concerning neurological disorders in infants and children, and to innovate more effective strategies for the prevention, management and resolution of neurological diseases, disorders and injuries. Our division continues to break new ground in the understanding of conditions ranging from epilepsy to autism to pediatric brain cancer.
The Rajadhyaksha Lab, led by Anjali Rajadhyaksha, PhD, is interested in understanding how L-type Cav1.2 and Cav1.3 calcium channels contribute to addiction and neuropsychiatric disorders. Their research is carried out using a range of pharmacological and genetic techniques in combination with behavioural assays, with the goal of elucidating the molecular contribution of Cav1.2 and Cav1.3 channels to neuropsychiatric-related endophenotypes. Ultimately, the lab aims to increase our knowledge of complex brain disorders towards the development of novel therapeutics.
Learn more: Rajadhyaksha Lab webpage
Weill Cornell Autism Research Program (WCARP)
The Weill Cornell Autism Research Program, directed by Dr. Anjali Rajadhyaksha, is a multi-institutional collaborative effort committed to advancing Autism Spectrum Disorder (ASD) knowledge, understanding the neurobiological basis of ASD, and supporting development of new diagnostic markers and treatments for patients with autism.
Pediatric Concussion & Mild Traumatic Brain Injury (MTBI) Program
Our pediatric concussion and MTBI team is dedicated to raising awareness and pursuing research to improve diagnostics and therapeutics for these widespread injuries.
Exercise Therapy as Treatment (ETT) for MTBI
Dr. Barry Kosofsky leads this longitudinal clinical research study testing early initiation of a graded exercise program to accelerate recovery. Dr. Kosofky’s team assesses individuals at risk for long-term deficits to identify those who might need earlier treatment, utilizing sophisticated physiologic measurements during exercise, as well as eye tracking and electrophysiologic assessments (EEG and ERP) to measure neurocognitive performance.
Public Safety & Healthcare Policy
Zachary Grinspan, M.D., M.S., Weill Cornell Medicine Division of Child Neurology, is currently conducting research that utilizes large clinical and administrative datasets to answer core questions for children with epilepsy. His projects include:
Rare Epilepsies in New York City (RENYC)
Rare epilepsies are a devastating group of diseases that begin in childhood and are often associated with profound neurologic, medical and psychiatric disabilities. Dr. Grinspan’s team collects electronic physician’s notes from five academic medical centers in New York City to identify cases and understand the essential epidemiology of this vulnerable and medically complex population. The team is also developing an easy-to-share tool to find rare epilepsies through an automated search of clinical notes.
Sudden Unexpected Death in Epilepsy (SUDEP)
Dr. Grinspan’s team reviews physician’s notes to understand how and when physicians counsel epileptic children about SUDEP.
Comparative Effectiveness for Infantile Spasms
Infantile spasms are devastating epilepsies of infancy that can cause permanent neurodevelopment disability. Dr. Grinspan’s team compares three recommended treatments (ACTH, oral steroids and vigabatrin) for infantile spasms, using several large datasets.
Dr. Grinspan’s team compares the effectiveness of commonly used medications for children three and younger with new onset epilepsy.
This project was initiated to develop tailored visualizations of clinical data to improve physician decision-making for children with neurological diseases in the ICU. Dr. Grinspan’s team aims to integrate cardiopulmonary physiology, neurophysiology, EEG, medications and laboratory values into a unified dashboard to assist with ongoing care.
EEG Signal Processing
Dr. Grinspan’s team explores novel techniques to view and interpret EEG signals using spectral analysis.
Health Services Research
The team explores how epileptic children use health services (doctor visits, imaging, EEGs, etc.).