The Child Neurology Division of Weill Cornell Medicine engages in a wide range of research activities to expand knowledge concerning neurological disorders in infants and children, and to innovate more effective strategies for the prevention, management and resolution of neurological diseases, disorders and injuries. Our division continues to break new ground in the understanding of conditions ranging from epilepsy to autism to pediatric brain cancer.
The Rajadhyaksha Lab, led by Anjali Rajadhyaksha, PhD, is interested in understanding how L-type Cav1.2 and Cav1.3 calcium channels contribute to addiction and neuropsychiatric disorders. Their research is carried out using a range of pharmacological and genetic techniques in combination with behavioural assays, with the goal of elucidating the molecular contribution of Cav1.2 and Cav1.3 channels to neuropsychiatric-related endophenotypes. Ultimately, the lab aims to increase our knowledge of complex brain disorders towards the development of novel therapeutics.
Learn more: Rajadhyaksha Lab webpage
Brain tumors are now the leading cause of disease-related death in children. The Laboratory for Childhood Brain Tumor Research, directed by Praveen Raju, M.D., Ph.D., is dedicated to understanding the molecular underpinnings of pediatric brain tumors through translationally-focused research, and developing novel therapeutic approaches to improve overall outcomes and minimize treatment-related toxicities in affected children. Dr. Raju’s primary research foci are medulloblastoma, the most common malignant childhood brain tumor, and the utilization of sophisticated mouse genetic techniques to improve current animal models of other pediatric neural cancers including DIPG, ATRT and NF-1-related Malignant Plexiform Nerve Sheath Tumors (MPNSTs).
- We are Weill Cornell Medicine: Dr. Praveen Raju
- Medulloblastoma Mouse Model May Help Reduce Treatment-Related Toxicity, Minimize Risk for Pediatric Brain Tumor Recurrence, NYP Focus on Pediatric Neurology and Neurosurgery (March 2017)
- Praveen Raju, M.D., Ph.D. – Memorial Sloan Kettering Cancer Center
The Weill Cornell Autism Research Program, directed by Dr. Anjali Rajadhyaksha, is a multi-institutional collaborative effort committed to advancing Autism Spectrum Disorder (ASD) knowledge, understanding the neurobiological basis of ASD, and supporting development of new diagnostic markers and treatments for patients with autism.
Our pediatric concussion and MTBI team is dedicated to raising awareness and pursuing research to improve diagnostics and therapeutics for these widespread injuries.
Dr. Barry Kosofsky leads this longitudinal clinical research study testing early initiation of a graded exercise program to accelerate recovery. Dr. Kosofky’s team assesses individuals at risk for long-term deficits to identify those who might need earlier treatment, utilizing sophisticated physiologic measurements during exercise, as well as eye tracking and electrophysiologic assessments (EEG and ERP) to measure neurocognitive performance.
Zachary Grinspan, M.D., M.S., Weill Cornell Medicine Division of Child Neurology, is currently conducting research that utilizes large clinical and administrative datasets to answer core questions for children with epilepsy. His projects include: