News

Director of Education for the Weill Cornell Medicine/NewYork-Presbyterian Simulation Center, Dr. Timothy Clapper received a grant from the NewYork-Presbyterian (NYP) MDxPx Program for his research, “An innovative instructional design model to improve delivery of bad or difficult news for PGY-2 residents across multiple specializations.”

 The award follows the NYP Patient Experience Group’s awarding Dr. Clapper funding to support the successful implementation of delivering bad or difficult news training for interdisciplinary fellows from five adult and pediatric subspecialty training fellowships.

 He and his co-researchers, including faculty and staff from our Department of Pediatrics (Aliza Solomon, DO; Christine Joyce, MD: Kevin Ching, MD; Winnie Shen, and Kyle P. Burns) found significant improvements in fellow’s ability to deliver difficult news and value for the evidence-based, innovation framework that includes targeted feedback.

Marisa Censani, MD, associate professor of clinical pediatrics and Director of the Pediatric Obesity Program in the Division of Pediatric Endocrinology, is co-investigator on a newly funded NIH study titled, “The preliminary efficacy of a culturally tailored, telehealth lifestyle intervention for Black adolescent girls with prediabetes: a pilot randomized controlled trial” (R21MD016986). The principal investigator is Tashara M. Leak, PhD, RD, an assistant professor in the Division of Nutritional Sciences (Cornell University, Ithaca, NY). For 12 weeks participants will engage in a weekly virtual wellness session focusing on mindfulness and nutrition, an at-home cooking experience preparing healthy ethnic meals, and a virtual Afrocentric dance class. The overall aim of the study is to improve diet quality, increase physical activity, and improve glycemic measures.   

Pediatric ICU Fellow, Dr. Priyanka Mehrotra has received the Bronze Snapshot Research Award from the Society of Critical Care Medicine for her study, “Timing of Tracheostomy in Critically Ill Infants and Children with Respiratory Failure: A PHIS Study."

Despite tracheostomy’s historical depth, the growing complexity of the pediatric patient requiring long-term ventilation makes the decision of when to undergo tracheostomy challenging, creating vast variability in practice standards for timing of tracheostomy insertion in pediatric patients. In this study, Dr. Mehrotra aims to contribute to the current literature on timing of pediatric tracheostomy. She will describe the timing of tracheostomy placement, associated demographics, and clinical characteristics in a large pediatric critical care cohort using the Pediatric Health Information system database. Dr. Mehrotra will then compare the clinical outcomes based on timing of tracheostomy.

Dr. Mehrotra's overall goal is to provide more data on pediatric tracheostomy timing and associated outcomes to alleviate the shared decision-making burden amongst physicians and parents when discussing this life-altering intervention.

Pediatric Rheumatology Fellow, Dr. William Ambler was selected as an NIH Metzger Scholar in Translational Research for his project, “Role of sex hormones in neutrophil sex differences in health and systemic lupus erythematosus.”

Neutrophils are a type of white blood cells, called leukocytes, that act as your immune system's first line of defense. They’re also known to display sexual differences in phenotype and function in healthy individuals. Female neutrophils are more mature, have a heightened response to type 1 interferon, and have reduced mitochondrial respiration. These differences are likely related to sex hormone exposure. In systemic lupus erythematosus (SLE), a disease with significant female bias, neutrophils play an important role in disease pathogenesis and disease-related tissue injury. In this study, Dr. Ambler will investigate the mechanism of sex hormonal impact on neutrophils in murine models and evaluate neutrophil sex differences in SLE patients.

 By understanding the mechanisms of sex differences in neutrophils, Dr. Ambler's study will provide insight into sex differences in the immune response in SLE disease pathogenesis as well as in many other diseases.

The Department of Pediatrics is pleased to announce the appointment of Tiffany Schumaker, DO as Medical Director of the Pediatric Specialty Practice at Weill Cornell Medicine. In this role, Dr. Schumaker will work with the Vice Chair for Ambulatory Care Services ‐ Access and Strategy (ACSAS) and Departmental Leadership on overseeing clinical, educational, and operational activities of physicians, advanced practice providers, and pediatric residents and specialty fellows in the Pediatric Specialty Practice.

 Dr. Schumaker is an assistant professor of clinical pediatrics at Weill Cornell Medicine and an assistant attending pediatrician at NewYork-Presbyterian Komansky Children's Hospital. She received her medical degree from New York College of Osteopathic Medicine where she was also awarded membership to the Psi Sigma Alpha National Osteopathic Honor Society. She completed her residency in Pediatrics as Chief Resident at Cohen’s Children’s Medical Center, Long Island Jewish Hospital and her fellowship in Pediatric Endocrinology at NewYork-Presbyterian/Weill Cornell Medical Center. She is board certified in pediatrics and pediatric endocrinology.

 Zenna Solomon, MD, a pulmonary fellow in the Department of Pediatrics, received funding for her study "Disbalance of Sphingolipids in Bronchopulmonary Dysplasia" as part of the Weill Cornell Medicine Multidisciplinary Approach Training in Respiratory Research T32 Trainee Grant.

Bronchopulmonary dysplasia (BPD), the lung disease associated with premature birth, often leads to long term consequences such as impaired lung growth, asthma, and early development of chronic obstructive pulmonary disease (COPD). The mechanisms for the development of lung disease need to be better understood. Given the emerging role of sphingolipids in lung growth, asthma and COPD, there is a gap in knowledge on these lipids in neonates. Dr. Solomon aims to understand if and how sphingolipids in premature infants are related to the development of bronchopulmonary dysplasia and its pulmonary consequences. She will study sphingolipid composition in airways of premature infants and its functional consequences on the development of obstructive airway disease.

 The overall goal of Dr. Solomon’s studies is to identify markers for the development of lung disease in premature infants that may help in the development of novel therapies.

Fanny Vatter, PhD, MSc received funding for her study, “The role of exercise-induced exosomes in breast cancer prevention” as part of the Weill Cornell Medicine CTSC TL1 Education Award.

 Epidemiological evidence suggests a high correlation between physical activity and cancer protection and survival. However, the underlying cellular mechanisms remain elusive. Exosomes are small vesicles released by all cell types and efficient messengers in tissue crosstalk. For this study, Dr. Vatter will investigate how exosomes mediate tissue crosstalk during exercise and may be responsible for the benefits of exercise in cancer prevention and survival. She will characterize the source and unique cargo of exosomes mediating cancer prevention and determine the mechanisms by which these exosomes prevent cancer growth and metastasis using murine models of exercise. Finally, in collaboration with Lee Jones, PhD, MSc, Professor of Physiology in Medicine at Weill Cornell Medicine, she will identify the exosome cargo from patients undergoing controlled exercise programs responsible for the beneficial effects of exercise, that can represent the basis of novel preventive or therapeutic strategies.

The Department of Pediatrics is pleased to announce the promotion of Shipra Kaicker, MD to Associate Professor of Clinical Pediatrics, effective January 1, 2022.

 Dr. Shipra Kaicker earned her medical school degree (MBBS) from the University of Delhi, New Delhi India in 1991. She then completed her first pediatric residency at Maulana Azad Medical College, University of Delhi in 1995. This was followed by a second pediatric residency in the U.S at St. Vincent’s Medical Center, New York Medical College, New York. Dr. Kaicker completed her Pediatric Hematology Oncology fellowship from Columbia University College of Physicians and Surgeons in 2003. Upon completion of her fellowship, Dr. Kaicker joined the Maimonides Infant’s and Children’s Hospital in Brooklyn, New York as an attending physician and full-time faculty, where she mentored and trained numerous pediatric residents and medical students.

This article was originally posted on WCM Newsroom.

Melanoma cells release small extracellular packages containing the protein nerve growth factor receptor, which primes nearby lymph nodes for tumor metastases, according to a new study by Weill Cornell Medicine researchers.

The study results, published on Nov. 25 in Nature Cancer, may one day help doctors determine which patients need more aggressive treatment and could help with the development of new therapies, said senior author, Dr. David Lyden, the Stavros S. Niarchos Professor in Pediatric Cardiology and a professor of pediatrics and of cell and developmental biology at Weill Cornell Medicine.

Traditionally, scientists have had a tumor-centric view of melanoma in which cells from the tumor break off and travel to nearby lymph nodes, as cancer metastasizes. “What our study shows is that the lymph node functionally prepares for future metastases,” said Dr. Lyden, who is also a member of the Gale and Ira Drukier Institute for Children’s Health and the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine. “There are many changes taking place in the lymph node even before the tumor cell gets there. We call it a pre-metastatic lymph node.”

Congratulations to Adin Nelson, MD, MHPE, Assistant Professor of Clinical Pediatrics, on receiving the Department of Pediatrics 2022 Pilot Award for his study, What Can One Practice Question a Day Do For Pediatrics Residents?

Dr. Nelson’s project is a national prospective study that will examine how answering daily multiple-choice practice questions can improve residents’ learning. There is a growing body of literature on the strategy of studying with review questions - called retrieval practice, but it’s never been tested on a large scale in the real world. Dr. Nelson is partnering with the American Academy of Pediatrics and the Association of Pediatrics Program Directors to study this technique, making it one of the largest prospective studies ever done in medical education.

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