The Division of Pediatric Infectious Diseases is engaged in basic, clinical and translational research.
Dr. Sallie Permar leads the Permar Lab, whose research focuses on the development of immunologic strategies to eliminate neonatal pathogens – with the ultimate goal of providing every child with a healthy start to life. The Permar Lab investigates the natural maternal and infant immune responses that contribute to impeding transmission of vertically transmitted viral pathogens, such as HIV, cytomegalovirus (CMV), and Zika, and how these effective immune responses can best targeted by vaccine approaches. The team is engaged in developing and utilizing nonhuman primate models of vertical virus transmission to perform proof of concept studies to determine whether the vaccine approaches that target the naturally protective immune responses are effective. Further, they are focusing on both innate and adaptive immune responses at the maternal-fetal interface, including mucosal surfaces and the immunology of breast milk.
For more information: Permar Lab
Dr. Christine Salvatore has conducted bench to bedside translational research trying to establish the effectiveness of fungal biomarkers, in particular (1->3)-ß-D-glucan, in the diagnosis and therapeutic monitoring of invasive fungal infections in pediatrics. Studying the epidemiology, diagnosis and treatment of joint and bone infections in children is another of her interests.
For more information, see Dr. Salvatore's VIVO page.